Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1040552..1041135 Replicon chromosome
Accession NZ_OW967795
Organism Escherichia coli isolate 538

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LQ148_RS04955 Protein ID WP_022296743.1
Coordinates 1040800..1041135 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LQ148_RS04950 Protein ID WP_022296742.1
Coordinates 1040552..1040800 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ148_RS04940 (1036891) 1036891..1038192 + 1302 WP_000046819.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
LQ148_RS04945 (1038240) 1038240..1040474 + 2235 WP_000226815.1 GTP pyrophosphokinase -
LQ148_RS04950 (1040552) 1040552..1040800 + 249 WP_022296742.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LQ148_RS04955 (1040800) 1040800..1041135 + 336 WP_022296743.1 endoribonuclease MazF Toxin
LQ148_RS04960 (1041207) 1041207..1041998 + 792 WP_001071631.1 nucleoside triphosphate pyrophosphohydrolase -
LQ148_RS04965 (1042226) 1042226..1043863 + 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
LQ148_RS04970 (1043951) 1043951..1045249 + 1299 WP_000036723.1 phosphopyruvate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12127.99 Da        Isoelectric Point: 8.4777

>T295828 WP_022296743.1 NZ_OW967795:1040800-1041135 [Escherichia coli]
MVSRYVPDTGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLYVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9297.70 Da        Isoelectric Point: 4.5837

>AT295828 WP_022296742.1 NZ_OW967795:1040552-1040800 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGAPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References