Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 884024..884678 Replicon chromosome
Accession NZ_OW967795
Organism Escherichia coli isolate 538

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag LQ148_RS04325 Protein ID WP_000244765.1
Coordinates 884271..884678 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag LQ148_RS04320 Protein ID WP_000354046.1
Coordinates 884024..884290 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ148_RS04300 (880112) 880112..881545 - 1434 WP_001339296.1 6-phospho-beta-glucosidase BglA -
LQ148_RS04305 (881590) 881590..881901 + 312 WP_001525592.1 N(4)-acetylcytidine aminohydrolase -
LQ148_RS04310 (882065) 882065..882724 + 660 WP_000250275.1 hemolysin III family protein -
LQ148_RS04315 (882801) 882801..883781 - 981 WP_000886080.1 tRNA-modifying protein YgfZ -
LQ148_RS04320 (884024) 884024..884290 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
LQ148_RS04325 (884271) 884271..884678 + 408 WP_000244765.1 protein YgfX Toxin
LQ148_RS04330 (884718) 884718..885239 - 522 WP_001055874.1 flavodoxin FldB -
LQ148_RS04335 (885351) 885351..886247 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
LQ148_RS04340 (886272) 886272..886982 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ148_RS04345 (886988) 886988..888721 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T295827 WP_000244765.1 NZ_OW967795:884271-884678 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT295827 WP_000354046.1 NZ_OW967795:884024-884290 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References