Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 290682..291482 Replicon chromosome
Accession NZ_OW967795
Organism Escherichia coli isolate 538

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag LQ148_RS01350 Protein ID WP_021555761.1
Coordinates 290955..291482 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag LQ148_RS01345 Protein ID WP_001277107.1
Coordinates 290682..290948 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ148_RS01320 (285992) 285992..286846 - 855 WP_000368745.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
LQ148_RS01325 (286839) 286839..287585 - 747 WP_000021882.1 PTS sugar transporter subunit IIC -
LQ148_RS01330 (287602) 287602..288087 - 486 WP_000029256.1 PTS sugar transporter subunit IIB -
LQ148_RS01335 (288094) 288094..288495 - 402 WP_001071333.1 PTS sugar transporter subunit IIA -
LQ148_RS01340 (289430) 289430..290533 + 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
LQ148_RS01345 (290682) 290682..290948 + 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
LQ148_RS01350 (290955) 290955..291482 + 528 WP_021555761.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
LQ148_RS01355 (291479) 291479..291862 - 384 WP_001525853.1 aspartate 1-decarboxylase autocleavage activator PanM -
LQ148_RS01360 (292286) 292286..293395 + 1110 WP_001297972.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
LQ148_RS01365 (293443) 293443..294369 + 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LQ148_RS01370 (294366) 294366..295643 + 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
LQ148_RS01375 (295640) 295640..296407 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(90-150)

Antitoxin

(8-86)


Sequences


Toxin        


Download         Length: 176 a.a.        Molecular weight: 19664.56 Da        Isoelectric Point: 6.4791

>T295825 WP_021555761.1 NZ_OW967795:290955-291482 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTQLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT295825 WP_001277107.1 NZ_OW967795:290682-290948 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References