Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 11120..11763 Replicon 2 plasmid P1
Accession NZ_OW967519
Organism Klebsiella oxytoca isolate

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag LQ214_RS28685 Protein ID WP_016236302.1
Coordinates 11347..11763 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag LQ214_RS28680 Protein ID WP_001261282.1
Coordinates 11120..11350 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ214_RS28655 (AI2744V1_5600) 6836..7093 - 258 WP_023292103.1 hypothetical protein -
LQ214_RS28660 7572..8300 + 729 Protein_6 CSS-motif domain-containing protein -
LQ214_RS28665 8316..9152 + 837 WP_032693954.1 EAL domain-containing protein -
LQ214_RS28670 (AI2744V1_5602) 9770..10201 - 432 WP_174805835.1 hypothetical protein -
LQ214_RS28675 10741..11163 - 423 WP_160887026.1 hypothetical protein -
LQ214_RS28680 (AI2744V1_5603) 11120..11350 + 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LQ214_RS28685 (AI2744V1_5604) 11347..11763 + 417 WP_016236302.1 type II toxin-antitoxin system VapC family toxin Toxin
LQ214_RS28690 (AI2744V1_5605) 11837..13399 + 1563 WP_004206609.1 AAA family ATPase -
LQ214_RS28695 (AI2744V1_5606) 13384..14406 + 1023 WP_000361404.1 helicase UvrD -
LQ214_RS28700 (AI2744V1_5607) 14951..15859 + 909 WP_032451458.1 HNH endonuclease -
LQ214_RS28705 (AI2744V1_5609) 16045..16395 - 351 WP_004187110.1 DUF305 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..195319 195319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15091.55 Da        Isoelectric Point: 7.1084

>T295821 WP_016236302.1 NZ_OW967519:11347-11763 [Klebsiella oxytoca]
VNKTYMLDTCICSFIMREQPEAVLKRLELAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT295821 WP_001261282.1 NZ_OW967519:11120-11350 [Klebsiella oxytoca]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References