295820

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX(toxin)
Location 4808168..4808987 Replicon chromosome
Accession NZ_OW967518
Organism Klebsiella oxytoca isolate

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag LQ214_RS22990 Protein ID WP_004110819.1
Coordinates 4808730..4808987 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag LQ214_RS22985 Protein ID WP_023320373.1
Coordinates 4808168..4808719 (-) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ214_RS22955 (AI2744V1_4507) 4803547..4804227 + 681 WP_023320375.1 nitroreductase -
LQ214_RS22960 (AI2744V1_4508) 4804235..4805437 - 1203 WP_023320374.1 multidrug effflux MFS transporter -
LQ214_RS22965 4805940..4806143 - 204 Protein_4525 VOC family protein -
LQ214_RS22970 (AI2744V1_4509) 4806143..4806352 - 210 WP_196089984.1 hypothetical protein -
LQ214_RS22975 4806522..4807286 - 765 WP_224226441.1 class I SAM-dependent methyltransferase -
LQ214_RS22980 4807680..4808054 - 375 Protein_4528 class I SAM-dependent methyltransferase -
LQ214_RS22985 (AI2744V1_4511) 4808168..4808719 - 552 WP_023320373.1 N-acetyltransferase Antitoxin
LQ214_RS22990 (AI2744V1_4512) 4808730..4808987 - 258 WP_004110819.1 YjhX family toxin Toxin
LQ214_RS22995 (AI2744V1_4513) 4809569..4810753 + 1185 WP_004099225.1 mannonate dehydratase -
LQ214_RS23000 (AI2744V1_4514) 4810828..4812303 + 1476 WP_004110817.1 fructuronate reductase -
LQ214_RS23005 (AI2744V1_4515) 4812439..4813215 + 777 WP_004099223.1 Uxu operon transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(17-130)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T295820 WP_004110819.1 NZ_OW967518:c4808987-4808730 [Klebsiella oxytoca]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20138.98 Da        Isoelectric Point: 6.8799

>AT295820 WP_023320373.1 NZ_OW967518:c4808719-4808168 [Klebsiella oxytoca]
MTNHNFTFHITSERDADDIREVETRAFGFSKEADLVAALLNDESAHPSLSLLAKHNGKAVGHILFTLATFKGESDSPMMH
ILAPLAVVPEYQGVGVGGLLIQRGIEHLKAAGSEAVFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMLQRLSS
RPLGRTGQIQCARALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure

References