295819

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4544667..4545286 Replicon chromosome
Accession NZ_OW967518
Organism Klebsiella oxytoca isolate

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag LQ214_RS21740 Protein ID WP_004099646.1
Coordinates 4545068..4545286 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag LQ214_RS21735 Protein ID WP_004099648.1
Coordinates 4544667..4545041 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ214_RS21725 (AI2744V1_4261) 4539823..4541016 + 1194 WP_004111040.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ214_RS21730 (AI2744V1_4262) 4541039..4544185 + 3147 WP_004099650.1 multidrug efflux RND transporter permease subunit AcrB -
LQ214_RS21735 (AI2744V1_4263) 4544667..4545041 + 375 WP_004099648.1 Hha toxicity modulator TomB Antitoxin
LQ214_RS21740 (AI2744V1_4264) 4545068..4545286 + 219 WP_004099646.1 HHA domain-containing protein Toxin
LQ214_RS21745 (AI2744V1_4265) 4545447..4546013 + 567 WP_023320460.1 maltose O-acetyltransferase -
LQ214_RS21750 4545982..4546119 - 138 WP_224226357.1 hypothetical protein -
LQ214_RS21755 (AI2744V1_4266) 4546150..4546620 + 471 WP_004111038.1 YlaC family protein -
LQ214_RS21760 (AI2744V1_4267) 4546595..4548049 - 1455 WP_023320459.1 PLP-dependent aminotransferase family protein -
LQ214_RS21765 (AI2744V1_4268) 4548151..4548849 + 699 WP_004099639.1 GNAT family protein -
LQ214_RS21770 (AI2744V1_4269) 4548846..4548986 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LQ214_RS21775 (AI2744V1_4270) 4548986..4549249 - 264 WP_004099638.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T295819 WP_004099646.1 NZ_OW967518:4545068-4545286 [Klebsiella oxytoca]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT295819 WP_004099648.1 NZ_OW967518:4544667-4545041 [Klebsiella oxytoca]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLVTQLDEYL
DDTFVLFSNYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure

References