Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1352623..1353395 Replicon chromosome
Accession NZ_OW967518
Organism Klebsiella oxytoca isolate

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag LQ214_RS06600 Protein ID WP_064351566.1
Coordinates 1352623..1352997 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag LQ214_RS06605 Protein ID WP_049115328.1
Coordinates 1353036..1353395 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ214_RS06575 (AI2744V1_1281) 1348567..1349469 - 903 WP_064351591.1 bacteriophage abortive infection AbiH family protein -
LQ214_RS06580 (AI2744V1_1282) 1349556..1349819 + 264 WP_228306239.1 hypothetical protein -
LQ214_RS06585 1350114..1350473 + 360 WP_228306240.1 hypothetical protein -
LQ214_RS06590 (AI2744V1_1283) 1351095..1352084 + 990 WP_064351567.1 glycosyltransferase -
LQ214_RS06595 (AI2744V1_1284) 1352088..1352543 + 456 WP_225373941.1 hypothetical protein -
LQ214_RS06600 (AI2744V1_1286) 1352623..1352997 - 375 WP_064351566.1 TA system toxin CbtA family protein Toxin
LQ214_RS06605 (AI2744V1_1287) 1353036..1353395 - 360 WP_049115328.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LQ214_RS06610 (AI2744V1_1288) 1353418..1353639 - 222 WP_064351565.1 DUF987 domain-containing protein -
LQ214_RS06615 (AI2744V1_1289) 1353653..1354135 - 483 WP_064351564.1 DNA repair protein RadC -
LQ214_RS06620 (AI2744V1_1290) 1354132..1354365 - 234 WP_064351563.1 hypothetical protein -
LQ214_RS06625 (AI2744V1_1291) 1354376..1354771 - 396 WP_162881977.1 antirestriction protein -
LQ214_RS06630 (AI2744V1_1292) 1354934..1355755 - 822 WP_064351561.1 DUF932 domain-containing protein -
LQ214_RS06635 (AI2744V1_1293) 1355862..1356074 - 213 WP_032755286.1 hypothetical protein -
LQ214_RS06640 (AI2744V1_1294) 1356160..1356519 - 360 WP_004136901.1 hypothetical protein -
LQ214_RS06645 (AI2744V1_1295) 1356574..1357038 - 465 WP_004136903.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1342087..1370180 28093


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(9-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13859.91 Da        Isoelectric Point: 10.0015

>T295814 WP_064351566.1 NZ_OW967518:c1352997-1352623 [Klebsiella oxytoca]
MQIQSLPPQRAASSRLSSVKIWQKLLEYLLEQHYGLTLNDTPFGNDSVIQKHIDAGISLCDAVNFIVEKYDLVRTDRHGF
SVKEQSPFIGSLDMLRARKATGLMTRKGYKTVTDITGGRFSGGK

Download         Length: 375 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13365.43 Da        Isoelectric Point: 7.3727

>AT295814 WP_049115328.1 NZ_OW967518:c1353395-1353036 [Klebsiella oxytoca]
MQKATRVINHNITEPWWGLRRNITPCFGARLVQEGNHLHYLADRASIAGTFNDADLRHLDQAFPVLMKQMELMLTSNELT
PHIQRCITIHAKGLICEADTLGSCGYLYIVIYPASATTA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References