Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 901618..902275 Replicon chromosome
Accession NZ_OW967518
Organism Klebsiella oxytoca isolate

Toxin (Protein)


Gene name cptA Uniprot ID A0A181X6I0
Locus tag LQ214_RS04420 Protein ID WP_004105559.1
Coordinates 901865..902275 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag LQ214_RS04415 Protein ID WP_004105561.1
Coordinates 901618..901884 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ214_RS04400 (AI2744V1_0856) 896871..897296 - 426 WP_004854067.1 PTS sugar transporter subunit IIA -
LQ214_RS04405 (AI2744V1_0857) 897417..900215 - 2799 WP_023321613.1 transcriptional regulator DagR -
LQ214_RS04410 (AI2744V1_0858) 900391..901374 - 984 WP_004115279.1 tRNA-modifying protein YgfZ -
LQ214_RS04415 (AI2744V1_0860) 901618..901884 + 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
LQ214_RS04420 (AI2744V1_0861) 901865..902275 + 411 WP_004105559.1 protein YgfX Toxin
LQ214_RS04425 (AI2744V1_0862) 902284..902805 - 522 WP_004105557.1 flavodoxin FldB -
LQ214_RS04430 (AI2744V1_0863) 902927..903823 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
LQ214_RS04435 (AI2744V1_0864) 903846..904559 + 714 WP_023321612.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ214_RS04440 (AI2744V1_0865) 904565..906298 + 1734 WP_004105553.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16061.83 Da        Isoelectric Point: 10.9455

>T295813 WP_004105559.1 NZ_OW967518:901865-902275 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQD

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT295813 WP_004105561.1 NZ_OW967518:901618-901884 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A181X6I0

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References