Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 107344..108967 | Replicon | plasmid P1 |
Accession | NZ_OW967389 | ||
Organism | Enterobacter cloacae isolate 114 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | C1IUI3 |
Locus tag | LQ218_RS23540 | Protein ID | WP_000088044.1 |
Coordinates | 107642..108967 (+) | Length | 442 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | A0A6M3PBR7 |
Locus tag | LQ218_RS23535 | Protein ID | WP_012477377.1 |
Coordinates | 107344..107637 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LQ218_RS23515 (AI2624V1_4564) | 103143..103535 | + | 393 | WP_000341066.1 | hypothetical protein | - |
LQ218_RS23520 (AI2624V1_4565) | 104194..104850 | + | 657 | WP_000462754.1 | trypsin-like serine protease | - |
LQ218_RS23525 (AI2624V1_4566) | 105053..105550 | + | 498 | WP_000340139.1 | membrane protein | - |
LQ218_RS23530 (AI2624V1_4567) | 105555..106943 | + | 1389 | WP_000083579.1 | hypothetical protein | - |
LQ218_RS23535 (AI2624V1_4568) | 107344..107637 | + | 294 | WP_012477377.1 | helix-turn-helix transcriptional regulator | Antitoxin |
LQ218_RS23540 (AI2624V1_4569) | 107642..108967 | + | 1326 | WP_000088044.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
LQ218_RS23545 (AI2624V1_4570) | 109028..109234 | + | 207 | WP_000134171.1 | hypothetical protein | - |
LQ218_RS23550 (AI2624V1_4571) | 109451..110431 | - | 981 | WP_000019450.1 | IS5-like element ISKpn26 family transposase | - |
LQ218_RS23555 (AI2624V1_4572) | 110477..111100 | - | 624 | WP_000490639.1 | hypothetical protein | - |
LQ218_RS23560 (AI2624V1_4573) | 111158..111538 | - | 381 | WP_001371925.1 | hypothetical protein | - |
LQ218_RS23565 | 112293..112463 | + | 171 | Protein_114 | transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | - | - | 1..213001 | 213001 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 442 a.a. Molecular weight: 50333.32 Da Isoelectric Point: 6.5044
>T295812 WP_000088044.1 NZ_OW967389:107642-108967 [Enterobacter cloacae]
MSRKQQRLAIWMNGIKVGYWEKSKGVDSLQYLPDWSADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMRSSVENEWLCSVLLEQYGLPVARTQIAHFEDQKALVVERF
DRKWSGNGQWIIRLPQEDMCQALGISPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIVFWMMAATDGHAKNFS
ISIGPQGRYHLTPLYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
MSRKQQRLAIWMNGIKVGYWEKSKGVDSLQYLPDWSADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMRSSVENEWLCSVLLEQYGLPVARTQIAHFEDQKALVVERF
DRKWSGNGQWIIRLPQEDMCQALGISPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIVFWMMAATDGHAKNFS
ISIGPQGRYHLTPLYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
Download Length: 1326 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2S1XXW1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6M3PBR7 |