Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3861217..3861874 Replicon chromosome
Accession NZ_OW967388
Organism Enterobacter cloacae isolate 114

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag LQ218_RS18580 Protein ID WP_022649305.1
Coordinates 3861217..3861627 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag LQ218_RS18585 Protein ID WP_003863437.1
Coordinates 3861608..3861874 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ218_RS18560 (AI2624V1_3608) 3857215..3858948 - 1734 WP_022651808.1 single-stranded-DNA-specific exonuclease RecJ -
LQ218_RS18565 (AI2624V1_3609) 3858954..3859667 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ218_RS18570 (AI2624V1_3610) 3859696..3860592 - 897 WP_022651809.1 site-specific tyrosine recombinase XerD -
LQ218_RS18575 (AI2624V1_3611) 3860694..3861215 + 522 WP_003863440.1 flavodoxin FldB -
LQ218_RS18580 (AI2624V1_3612) 3861217..3861627 - 411 WP_022649305.1 protein YgfX Toxin
LQ218_RS18585 (AI2624V1_3613) 3861608..3861874 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
LQ218_RS18590 (AI2624V1_3614) 3862169..3863149 + 981 WP_003863435.1 tRNA-modifying protein YgfZ -
LQ218_RS18595 (AI2624V1_3616) 3863235..3863894 - 660 WP_003863433.1 hemolysin III family protein -
LQ218_RS18600 (AI2624V1_3617) 3864161..3864892 + 732 WP_003863431.1 MurR/RpiR family transcriptional regulator -
LQ218_RS18605 (AI2624V1_3618) 3865009..3866442 + 1434 WP_022651811.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T295811 WP_022649305.1 NZ_OW967388:c3861627-3861217 [Enterobacter cloacae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT295811 WP_003863437.1 NZ_OW967388:c3861874-3861608 [Enterobacter cloacae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References