Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA(toxin) |
Location | 3117190..3118973 | Replicon | chromosome |
Accession | NZ_OW967388 | ||
Organism | Enterobacter cloacae isolate 114 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | A0A8B5ZXW9 |
Locus tag | LQ218_RS15095 | Protein ID | WP_022651516.1 |
Coordinates | 3117190..3118539 (+) | Length | 450 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | A0A837FFV9 |
Locus tag | LQ218_RS15100 | Protein ID | WP_003859317.1 |
Coordinates | 3118536..3118973 (+) | Length | 146 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LQ218_RS15070 (AI2624V1_2935) | 3113013..3113948 | - | 936 | WP_003859306.1 | tRNA dihydrouridine(16) synthase DusC | - |
LQ218_RS15075 (AI2624V1_2936) | 3114117..3114512 | + | 396 | WP_003859308.1 | CidA/LrgA family protein | - |
LQ218_RS15080 (AI2624V1_2937) | 3114509..3115204 | + | 696 | WP_003859310.1 | CidB/LrgB family autolysis modulator | - |
LQ218_RS15085 (AI2624V1_2938) | 3115333..3116217 | + | 885 | WP_022651515.1 | cytidine deaminase | - |
LQ218_RS15090 (AI2624V1_2939) | 3116345..3117055 | + | 711 | WP_250249391.1 | outer membrane permeability protein SanA | - |
LQ218_RS15095 (AI2624V1_2940) | 3117190..3118539 | + | 1350 | WP_022651516.1 | HipA domain-containing protein | Toxin |
LQ218_RS15100 (AI2624V1_2941) | 3118536..3118973 | + | 438 | WP_003859317.1 | helix-turn-helix transcriptional regulator | Antitoxin |
LQ218_RS15105 (AI2624V1_2942) | 3119012..3120022 | - | 1011 | WP_003859318.1 | galactose/methyl galactoside ABC transporter permease MglC | - |
LQ218_RS15110 (AI2624V1_2943) | 3120038..3121558 | - | 1521 | WP_003859320.1 | galactose/methyl galactoside ABC transporter ATP-binding protein MglA | - |
LQ218_RS15115 (AI2624V1_2944) | 3121638..3122636 | - | 999 | WP_003859322.1 | galactose/glucose ABC transporter substrate-binding protein MglB | - |
LQ218_RS15120 (AI2624V1_2945) | 3122932..3123954 | - | 1023 | WP_003859324.1 | HTH-type transcriptional regulator GalS | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 450 a.a. Molecular weight: 51151.85 Da Isoelectric Point: 4.7049
>T295810 WP_022651516.1 NZ_OW967388:3117190-3118539 [Enterobacter cloacae]
METLTVQAYLNETWTDIALIKYPGSEKKDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL
METLTVQAYLNETWTDIALIKYPGSEKKDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL
Download Length: 1350 bp
Antitoxin
Download Length: 146 a.a. Molecular weight: 16185.64 Da Isoelectric Point: 10.5154
>AT295810 WP_003859317.1 NZ_OW967388:3118536-3118973 [Enterobacter cloacae]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS
Download Length: 438 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A8B5ZXW9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A837FFV9 |