Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2305846..2306585 Replicon chromosome
Accession NZ_OW967388
Organism Enterobacter cloacae isolate 114

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag LQ218_RS11135 Protein ID WP_003857133.1
Coordinates 2305846..2306331 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag LQ218_RS11140 Protein ID WP_003857131.1
Coordinates 2306319..2306585 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ218_RS11120 (AI2624V1_2163) 2302713..2304146 - 1434 WP_004016055.1 restriction endonuclease -
LQ218_RS11125 (AI2624V1_2164) 2304167..2304970 - 804 WP_039268887.1 TIGR02391 family protein -
LQ218_RS11130 (AI2624V1_2165) 2304992..2305471 - 480 WP_001542736.1 hypothetical protein -
LQ218_RS11135 (AI2624V1_2166) 2305846..2306331 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
LQ218_RS11140 (AI2624V1_2167) 2306319..2306585 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
LQ218_RS11145 (AI2624V1_2168) 2306649..2307578 - 930 WP_022651200.1 LysR family transcriptional regulator -
LQ218_RS11150 (AI2624V1_2169) 2307708..2309096 + 1389 WP_032645625.1 MFS transporter -
LQ218_RS11155 (AI2624V1_2170) 2309118..2310113 - 996 WP_003857125.1 DUF2891 domain-containing protein -
LQ218_RS11160 (AI2624V1_2171) 2310123..2311109 - 987 WP_022651202.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2284376..2306585 22209


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T295805 WP_003857133.1 NZ_OW967388:c2306331-2305846 [Enterobacter cloacae]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT295805 WP_003857131.1 NZ_OW967388:c2306585-2306319 [Enterobacter cloacae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References