Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1081820..1082440 Replicon chromosome
Accession NZ_OW967388
Organism Enterobacter cloacae isolate 114

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag LQ218_RS05135 Protein ID WP_015571250.1
Coordinates 1081820..1082038 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag LQ218_RS05140 Protein ID WP_006809850.1
Coordinates 1082066..1082440 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ218_RS05105 (AI2624V1_0989) 1077832..1078092 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
LQ218_RS05110 (AI2624V1_0990) 1078095..1078235 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LQ218_RS05115 (AI2624V1_0991) 1078232..1078942 - 711 WP_022650493.1 GNAT family protein -
LQ218_RS05120 (AI2624V1_0992) 1079044..1080504 + 1461 WP_022650494.1 PLP-dependent aminotransferase family protein -
LQ218_RS05125 (AI2624V1_0993) 1080476..1080943 - 468 WP_022650495.1 YlaC family protein -
LQ218_RS05130 (AI2624V1_0994) 1081060..1081611 - 552 WP_022650496.1 maltose O-acetyltransferase -
LQ218_RS05135 (AI2624V1_0995) 1081820..1082038 - 219 WP_015571250.1 HHA domain-containing protein Toxin
LQ218_RS05140 (AI2624V1_0996) 1082066..1082440 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
LQ218_RS05145 (AI2624V1_0997) 1082951..1086097 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit AcrB -
LQ218_RS05150 (AI2624V1_0998) 1086120..1087313 - 1194 WP_058647476.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T295802 WP_015571250.1 NZ_OW967388:c1082038-1081820 [Enterobacter cloacae]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT295802 WP_006809850.1 NZ_OW967388:c1082440-1082066 [Enterobacter cloacae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References