Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 581392..582095 Replicon chromosome
Accession NZ_OW967388
Organism Enterobacter cloacae isolate 114

Toxin (Protein)


Gene name ypjF Uniprot ID A0A8B5ZZ18
Locus tag LQ218_RS02790 Protein ID WP_039268718.1
Coordinates 581754..582095 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A8B5ZWQ9
Locus tag LQ218_RS02785 Protein ID WP_039268717.1
Coordinates 581392..581733 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ218_RS02750 (AI2624V1_0526) 576545..577420 + 876 WP_039268712.1 GTPase family protein -
LQ218_RS02755 (AI2624V1_0527) 577664..578380 + 717 WP_039268713.1 WYL domain-containing protein -
LQ218_RS02760 578416..578868 + 453 WP_039269148.1 hypothetical protein -
LQ218_RS02765 (AI2624V1_0530) 578940..579413 + 474 WP_039268714.1 hypothetical protein -
LQ218_RS02770 (AI2624V1_0531) 579534..580355 + 822 WP_039268715.1 DUF932 domain-containing protein -
LQ218_RS02775 (AI2624V1_0532) 580386..580826 + 441 WP_039268716.1 antirestriction protein -
LQ218_RS02780 (AI2624V1_0533) 580839..581381 + 543 WP_045259572.1 DNA repair protein RadC -
LQ218_RS02785 (AI2624V1_0534) 581392..581733 + 342 WP_039268717.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LQ218_RS02790 (AI2624V1_0535) 581754..582095 + 342 WP_039268718.1 TA system toxin CbtA family protein Toxin
LQ218_RS02795 (AI2624V1_0536) 582350..583357 + 1008 WP_039268719.1 restriction endonuclease -
LQ218_RS02800 583537..584373 - 837 Protein_537 HNH endonuclease -
LQ218_RS02805 (AI2624V1_0540) 584673..585140 + 468 WP_022650322.1 SymE family type I addiction module toxin -
LQ218_RS02810 (AI2624V1_0541) 585198..585569 - 372 WP_022650323.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island fosA - 536451..590040 53589


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12772.83 Da        Isoelectric Point: 9.6548

>T295801 WP_039268718.1 NZ_OW967388:581754-582095 [Enterobacter cloacae]
MKTLPATTPQAAKLCLLPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12729.40 Da        Isoelectric Point: 6.9460

>AT295801 WP_039268717.1 NZ_OW967388:581392-581733 [Enterobacter cloacae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRVSITGKFSEAECLKLDVAFPHFISQMESMLTTGGMNPRH
AHCVTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5ZZ18

Antitoxin

Source ID Structure
AlphaFold DB A0A8B5ZWQ9

References