Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 298080..298676 Replicon chromosome
Accession NZ_OW967388
Organism Enterobacter cloacae isolate 114

Toxin (Protein)


Gene name PumA Uniprot ID A0A5D9Q9B8
Locus tag LQ218_RS01430 Protein ID WP_003860348.1
Coordinates 298374..298676 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A837FG03
Locus tag LQ218_RS01425 Protein ID WP_022650216.1
Coordinates 298080..298367 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ218_RS01420 (AI2624V1_0269) 296452..298083 + 1632 WP_003860350.1 Na/Pi cotransporter family protein -
LQ218_RS01425 (AI2624V1_0270) 298080..298367 - 288 WP_022650216.1 putative addiction module antidote protein Antitoxin
LQ218_RS01430 (AI2624V1_0271) 298374..298676 - 303 WP_003860348.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ218_RS01435 (AI2624V1_0272) 298874..299746 + 873 WP_003860347.1 23S rRNA pseudouridine(2604) synthase RluF -
LQ218_RS01440 (AI2624V1_0273) 299747..300019 - 273 WP_003860346.1 DUF3811 domain-containing protein -
LQ218_RS01445 (AI2624V1_0274) 300070..301014 - 945 WP_022650218.1 ketopantoate/pantoate/pantothenate transporter PanS -
LQ218_RS01450 (AI2624V1_0275) 301108..302457 - 1350 WP_003860344.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11393.20 Da        Isoelectric Point: 10.1042

>T295800 WP_003860348.1 NZ_OW967388:c298676-298374 [Enterobacter cloacae]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHLGPGYRVYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10087.57 Da        Isoelectric Point: 5.7807

>AT295800 WP_022650216.1 NZ_OW967388:c298367-298080 [Enterobacter cloacae]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5D9Q9B8

Antitoxin

Source ID Structure
AlphaFold DB A0A837FG03

References