295799

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 54874..55610 Replicon plasmid P1
Accession NZ_OW967375
Organism Klebsiella oxytoca isolate 145

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag LQ212_RS28635 Protein ID WP_003026803.1
Coordinates 55128..55610 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag LQ212_RS28630 Protein ID WP_003026799.1
Coordinates 54874..55140 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ212_RS28585 (AI2623V1_5577) 50936..51298 - 363 WP_004152100.1 arsenite efflux transporter metallochaperone ArsD -
LQ212_RS28590 (AI2623V1_5578) 51348..51698 - 351 WP_004152101.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
LQ212_RS28595 (AI2623V1_5579) 52056..52325 + 270 WP_004152102.1 hypothetical protein -
LQ212_RS28600 (AI2623V1_5580) 52313..52888 + 576 WP_004152103.1 hypothetical protein -
LQ212_RS28605 (AI2623V1_5581) 52919..53413 + 495 WP_004152104.1 DNA-binding protein -
LQ212_RS28610 (AI2623V1_5582) 53457..53825 + 369 WP_004152105.1 hypothetical protein -
LQ212_RS28615 (AI2623V1_5583) 53859..54062 + 204 WP_004152106.1 HHA domain-containing protein -
LQ212_RS28620 (AI2623V1_5584) 54111..54368 + 258 WP_004152107.1 hypothetical protein -
LQ212_RS28625 (AI2623V1_5585) 54444..54698 + 255 WP_004152108.1 hypothetical protein -
LQ212_RS28630 (AI2623V1_5586) 54874..55140 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
LQ212_RS28635 (AI2623V1_5587) 55128..55610 + 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
LQ212_RS28640 (AI2623V1_5588) 55811..57214 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
LQ212_RS28645 (AI2623V1_5589) 57243..57875 - 633 WP_001567369.1 hypothetical protein -
LQ212_RS28650 (AI2623V1_5590) 58101..59447 + 1347 WP_077253535.1 ISNCY family transposase -
LQ212_RS28655 (AI2623V1_5591) 59496..59891 + 396 WP_004143398.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / blaCTX-M-15 / dfrA14 / qnrB1 / tet(A) / aac(6')-Ib-cr / blaOXA-1 / aac(3)-IIa - 1..253358 253358


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T295799 WP_003026803.1 NZ_OW967375:55128-55610 [Klebsiella oxytoca]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT295799 WP_003026799.1 NZ_OW967375:54874-55140 [Klebsiella oxytoca]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References