Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 5269128..5269820 Replicon chromosome
Accession NZ_OW967374
Organism Klebsiella oxytoca isolate 145

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag LQ212_RS24945 Protein ID WP_102804018.1
Coordinates 5269128..5269478 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag LQ212_RS24950 Protein ID WP_142385465.1
Coordinates 5269503..5269820 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ212_RS24920 (AI2623V1_4876) 5264987..5265784 - 798 WP_123830111.1 helix-turn-helix transcriptional regulator -
LQ212_RS24925 (AI2623V1_4877) 5265928..5266761 - 834 WP_153675657.1 DUF4942 domain-containing protein -
LQ212_RS24930 (AI2623V1_4878) 5266909..5267643 - 735 WP_123830109.1 retron system putative HNH endonuclease -
LQ212_RS24935 5267640..5267789 - 150 WP_153675655.1 hypothetical protein -
LQ212_RS24940 (AI2623V1_4879) 5267792..5269034 - 1243 Protein_4908 AAA family ATPase -
LQ212_RS24945 (AI2623V1_4880) 5269128..5269478 - 351 WP_102804018.1 TA system toxin CbtA family protein Toxin
LQ212_RS24950 (AI2623V1_4881) 5269503..5269820 - 318 WP_142385465.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LQ212_RS24955 (AI2623V1_4882) 5269878..5270099 - 222 WP_102804016.1 DUF987 domain-containing protein -
LQ212_RS24960 (AI2623V1_4883) 5270113..5270592 - 480 WP_047724681.1 DNA repair protein RadC -
LQ212_RS24965 (AI2623V1_4884) 5270605..5271054 - 450 WP_102804015.1 antirestriction protein -
LQ212_RS24970 (AI2623V1_4885) 5271087..5271908 - 822 WP_102804014.1 DUF932 domain-containing protein -
LQ212_RS24975 5272584..5273055 + 472 Protein_4915 transposase -
LQ212_RS24980 (AI2623V1_4887) 5272994..5273233 + 240 Protein_4916 IS66 family insertion sequence element accessory protein TnpB -
LQ212_RS24985 (AI2623V1_4888) 5273603..5274340 + 738 WP_047935074.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 5272994..5273251 257


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(4-104)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13220.22 Da        Isoelectric Point: 8.1282

>T295798 WP_102804018.1 NZ_OW967374:c5269478-5269128 [Klebsiella oxytoca]
MKTLPANQWVAKPCPPPVLVWQTLLTRLLEQHYGLTLNDTPFSDETVIQEHINAGTTLADAVNFLVEKYELVRIDRRGFN
CQEQSPYLRAVDILRARQATGLLTQCKKRKCNQPDG

Download         Length: 351 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12010.72 Da        Isoelectric Point: 6.9462

>AT295798 WP_142385465.1 NZ_OW967374:c5269820-5269503 [Klebsiella oxytoca]
MSEPWWGLRRSVSPCFGARLVQEGNRLHYLADRANFDGQFCDADLRHLDQAFPVLMKQLELMLTSGELNPRHLHCVTLYA
RGLTCEADTLGSHGYVYIAIYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References