295796

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4527434..4528053 Replicon chromosome
Accession NZ_OW967374
Organism Klebsiella oxytoca isolate 145

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag LQ212_RS21545 Protein ID WP_004099646.1
Coordinates 4527835..4528053 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag LQ212_RS21540 Protein ID WP_004099648.1
Coordinates 4527434..4527808 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ212_RS21530 (AI2623V1_4218) 4522590..4523783 + 1194 WP_004111040.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ212_RS21535 (AI2623V1_4219) 4523806..4526952 + 3147 WP_004099650.1 multidrug efflux RND transporter permease subunit AcrB -
LQ212_RS21540 (AI2623V1_4220) 4527434..4527808 + 375 WP_004099648.1 Hha toxicity modulator TomB Antitoxin
LQ212_RS21545 (AI2623V1_4221) 4527835..4528053 + 219 WP_004099646.1 HHA domain-containing protein Toxin
LQ212_RS21550 (AI2623V1_4222) 4528214..4528780 + 567 WP_064344889.1 maltose O-acetyltransferase -
LQ212_RS21555 4528749..4528886 - 138 WP_224226357.1 hypothetical protein -
LQ212_RS21560 (AI2623V1_4223) 4528917..4529387 + 471 WP_004099643.1 YlaC family protein -
LQ212_RS21565 (AI2623V1_4224) 4529362..4530816 - 1455 WP_064344888.1 PLP-dependent aminotransferase family protein -
LQ212_RS21570 (AI2623V1_4225) 4530919..4531617 + 699 WP_004099639.1 GNAT family protein -
LQ212_RS21575 (AI2623V1_4226) 4531614..4531754 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LQ212_RS21580 (AI2623V1_4227) 4531754..4532017 - 264 WP_004099638.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T295796 WP_004099646.1 NZ_OW967374:4527835-4528053 [Klebsiella oxytoca]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT295796 WP_004099648.1 NZ_OW967374:4527434-4527808 [Klebsiella oxytoca]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLVTQLDEYL
DDTFVLFSNYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure

References