Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 873075..873732 Replicon chromosome
Accession NZ_OW967374
Organism Klebsiella oxytoca isolate 145

Toxin (Protein)


Gene name cptA Uniprot ID A0A181X6I0
Locus tag LQ212_RS04225 Protein ID WP_004105559.1
Coordinates 873322..873732 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag LQ212_RS04220 Protein ID WP_004105561.1
Coordinates 873075..873341 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ212_RS04195 (AI2623V1_0824) 868255..869688 - 1434 WP_064343807.1 6-phospho-beta-glucosidase BglA -
LQ212_RS04200 (AI2623V1_0825) 869809..870537 - 729 WP_064352017.1 MurR/RpiR family transcriptional regulator -
LQ212_RS04205 (AI2623V1_0826) 870588..870899 + 312 WP_004105571.1 N(4)-acetylcytidine aminohydrolase -
LQ212_RS04210 (AI2623V1_0827) 871061..871720 + 660 WP_064344096.1 hemolysin III family protein -
LQ212_RS04215 (AI2623V1_0828) 871848..872831 - 984 WP_004115279.1 tRNA-modifying protein YgfZ -
LQ212_RS04220 (AI2623V1_0830) 873075..873341 + 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
LQ212_RS04225 (AI2623V1_0831) 873322..873732 + 411 WP_004105559.1 protein YgfX Toxin
LQ212_RS04230 (AI2623V1_0832) 873741..874262 - 522 WP_004105557.1 flavodoxin FldB -
LQ212_RS04235 (AI2623V1_0833) 874384..875280 + 897 WP_064343806.1 site-specific tyrosine recombinase XerD -
LQ212_RS04240 (AI2623V1_0834) 875303..876016 + 714 WP_064343805.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ212_RS04245 (AI2623V1_0835) 876022..877755 + 1734 WP_004105553.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16061.83 Da        Isoelectric Point: 10.9455

>T295790 WP_004105559.1 NZ_OW967374:873322-873732 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQD

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT295790 WP_004105561.1 NZ_OW967374:873075-873341 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A181X6I0

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References