Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 61083..61630 Replicon chromosome
Accession NZ_OW967374
Organism Klebsiella oxytoca isolate 145

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag LQ212_RS00305 Protein ID WP_064344021.1
Coordinates 61083..61391 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag LQ212_RS00310 Protein ID WP_064344020.1
Coordinates 61394..61630 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ212_RS00275 (AI2623V1_0055) 56730..57041 - 312 WP_004107048.1 PTS sugar transporter subunit IIB -
LQ212_RS00280 (AI2623V1_0056) 57336..58277 + 942 WP_064344024.1 LacI family DNA-binding transcriptional regulator -
LQ212_RS00285 (AI2623V1_0057) 58301..58597 - 297 WP_224250553.1 YicS family protein -
LQ212_RS00290 (AI2623V1_0058) 58808..59770 + 963 WP_064344105.1 Rpn family recombination-promoting nuclease/putative transposase -
LQ212_RS00295 (AI2623V1_0059) 59770..60027 + 258 WP_064344022.1 hypothetical protein -
LQ212_RS00300 (AI2623V1_0060) 60031..60933 - 903 WP_004107039.1 DMT family transporter -
LQ212_RS00305 (AI2623V1_0061) 61083..61391 - 309 WP_064344021.1 CcdB family protein Toxin
LQ212_RS00310 (AI2623V1_0062) 61394..61630 - 237 WP_064344020.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LQ212_RS00315 (AI2623V1_0063) 61736..63169 - 1434 WP_064344019.1 PTS N-acetylmuramic acid transporter subunit IIBC -
LQ212_RS00320 (AI2623V1_0064) 63194..64096 - 903 WP_064344104.1 N-acetylmuramic acid 6-phosphate etherase -
LQ212_RS00325 (AI2623V1_0065) 64258..65424 - 1167 WP_064344018.1 multidrug effflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11726.51 Da        Isoelectric Point: 6.2188

>T295789 WP_064344021.1 NZ_OW967374:c61391-61083 [Klebsiella oxytoca]
MQYYVYKNTGRIAAYPYLLDVQSDIIGERNTRVVIPLFPLKNYKGPRADRLTPLVTVEGEEYVVMTHELASIPHRVLGEE
VCNLNHQREVVKASMDFLFDGI

Download         Length: 309 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8768.95 Da        Isoelectric Point: 5.7928

>AT295789 WP_064344020.1 NZ_OW967374:c61630-61394 [Klebsiella oxytoca]
MPAAKRNKQNVSVTLDPGLVKQAREVGINLSLTLTNALKSEIHSLEIARWQKENALAIDYLNNLTEENGLLSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References