Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 43586..44111 Replicon plasmid P1
Accession NZ_OW967264
Organism Citrobacter freundii isolate 22

Toxin (Protein)


Gene name ccdB Uniprot ID W8EAA6
Locus tag LQ176_RS25055 Protein ID WP_008322213.1
Coordinates 43586..43891 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A6C0NE25
Locus tag LQ176_RS25060 Protein ID WP_032934863.1
Coordinates 43893..44111 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ176_RS25030 (AI2826V1_4861) 39418..40056 + 639 WP_008322203.1 aldolase -
LQ176_RS25035 (AI2826V1_4862) 40061..40837 + 777 WP_008322204.1 HPr family phosphocarrier protein -
LQ176_RS25040 (AI2826V1_4863) 40923..42290 + 1368 WP_008322207.1 GntP family transporter -
LQ176_RS25045 (AI2826V1_4864) 42489..43280 - 792 WP_008322208.1 site-specific integrase -
LQ176_RS25050 (AI2826V1_4865) 43270..43584 - 315 WP_008322211.1 hypothetical protein -
LQ176_RS25055 (AI2826V1_4866) 43586..43891 - 306 WP_008322213.1 type II toxin-antitoxin system toxin CcdB Toxin
LQ176_RS25060 (AI2826V1_4867) 43893..44111 - 219 WP_032934863.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
LQ176_RS25065 (AI2826V1_4868) 44823..45797 - 975 WP_181219984.1 sensor domain-containing diguanylate cyclase -
LQ176_RS25080 (AI2826V1_4873) 47911..48540 - 630 WP_181219980.1 IS6 family transposase -
LQ176_RS25085 (AI2826V1_4874) 48531..49043 + 513 WP_230133460.1 DM13 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..112775 112775
- inside IScluster/Tn - - 45944..66972 21028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11450.23 Da        Isoelectric Point: 5.8211

>T295786 WP_008322213.1 NZ_OW967264:c43891-43586 [Citrobacter freundii]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLVSARLLSDKVSRELYPVVSVGGDPYRLMTTDMASVPATVIGEEV
ADLSHLENDIQNAINLMFRGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8297.11 Da        Isoelectric Point: 4.4013

>AT295786 WP_032934863.1 NZ_OW967264:c44111-43893 [Citrobacter freundii]
VKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C0NE27

Antitoxin

Source ID Structure
AlphaFold DB A0A6C0NE25

References