Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4889510..4890126 Replicon chromosome
Accession NZ_OW967263
Organism Citrobacter freundii isolate 22

Toxin (Protein)


Gene name vapC Uniprot ID A0A0J1MQ96
Locus tag LQ176_RS23815 Protein ID WP_003028682.1
Coordinates 4889510..4889884 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6B5NTK4
Locus tag LQ176_RS23820 Protein ID WP_043018956.1
Coordinates 4889884..4890126 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ176_RS23800 (4887013) 4887013..4887915 + 903 WP_003028691.1 formate dehydrogenase O subunit beta -
LQ176_RS23805 (4887912) 4887912..4888547 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
LQ176_RS23810 (4888544) 4888544..4889473 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
LQ176_RS23815 (4889510) 4889510..4889884 - 375 WP_003028682.1 type II toxin-antitoxin system VapC family toxin Toxin
LQ176_RS23820 (4889884) 4889884..4890126 - 243 WP_043018956.1 CopG family transcriptional regulator Antitoxin
LQ176_RS23825 (4890332) 4890332..4891240 + 909 WP_044701816.1 alpha/beta hydrolase -
LQ176_RS23830 (4891391) 4891391..4892332 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
LQ176_RS23835 (4892377) 4892377..4892814 - 438 WP_003028671.1 D-aminoacyl-tRNA deacylase -
LQ176_RS23840 (4892811) 4892811..4893683 - 873 WP_003028669.1 virulence factor BrkB family protein -
LQ176_RS23845 (4893677) 4893677..4894276 - 600 WP_016151258.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13674.89 Da        Isoelectric Point: 9.5622

>T295785 WP_003028682.1 NZ_OW967263:c4889884-4889510 [Citrobacter freundii]
MVKGSALFDTNILIDLFSGRNEAKLAIETWPPQNAISLITWMEVMVGAKKYHQEARTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTKDFAGLSGVVTPYTL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9451.75 Da        Isoelectric Point: 4.3437

>AT295785 WP_043018956.1 NZ_OW967263:c4890126-4889884 [Citrobacter freundii]
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MQ96

Antitoxin

Source ID Structure
AlphaFold DB A0A6B5NTK4

References