Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4737573..4738239 Replicon chromosome
Accession NZ_OW967263
Organism Citrobacter freundii isolate 22

Toxin (Protein)


Gene name tad Uniprot ID A0A0D7LIM5
Locus tag LQ176_RS23130 Protein ID WP_044702260.1
Coordinates 4737880..4738239 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A0D7LIR0
Locus tag LQ176_RS23125 Protein ID WP_003844682.1
Coordinates 4737573..4737890 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ176_RS23095 (4733240) 4733240..4734064 + 825 WP_003031641.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
LQ176_RS23100 (4734133) 4734133..4735356 + 1224 WP_044702265.1 L-sorbose 1-phosphate reductase -
LQ176_RS23105 (4735358) 4735358..4736170 + 813 WP_044702264.1 shikimate 5-dehydrogenase -
LQ176_RS23110 (4736222) 4736222..4736578 - 357 WP_032948294.1 hypothetical protein -
LQ176_RS23115 (4736720) 4736720..4736881 + 162 WP_003841416.1 phage protein -
LQ176_RS23120 (4737285) 4737285..4737563 + 279 WP_044702262.1 putative addiction module antidote protein -
LQ176_RS23125 (4737573) 4737573..4737890 - 318 WP_003844682.1 helix-turn-helix transcriptional regulator Antitoxin
LQ176_RS23130 (4737880) 4737880..4738239 - 360 WP_044702260.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ176_RS23135 (4738453) 4738453..4739142 + 690 WP_003841421.1 dipeptidase PepE -
LQ176_RS23140 (4739208) 4739208..4740839 - 1632 WP_032938230.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13437.49 Da        Isoelectric Point: 10.2555

>T295784 WP_044702260.1 NZ_OW967263:c4738239-4737880 [Citrobacter freundii]
MTKPLYWVGQARKDLIAMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGNAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVT

Download         Length: 360 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11466.35 Da        Isoelectric Point: 9.0005

>AT295784 WP_003844682.1 NZ_OW967263:c4737890-4737573 [Citrobacter freundii]
MSHDVETSSGNVYADLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNMSGKLKVKFG

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7LIM5

Antitoxin

Source ID Structure
AlphaFold DB A0A0D7LIR0

References