Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3791799..3792419 Replicon chromosome
Accession NZ_OW967263
Organism Citrobacter freundii isolate 22

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LQ176_RS18610 Protein ID WP_002892050.1
Coordinates 3792201..3792419 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag LQ176_RS18605 Protein ID WP_003021733.1
Coordinates 3791799..3792173 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ176_RS18595 (3786946) 3786946..3788139 + 1194 WP_003835922.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ176_RS18600 (3788162) 3788162..3791311 + 3150 WP_003021736.1 efflux RND transporter permease AcrB -
LQ176_RS18605 (3791799) 3791799..3792173 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
LQ176_RS18610 (3792201) 3792201..3792419 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LQ176_RS18615 (3792726) 3792726..3793277 + 552 WP_044699372.1 maltose O-acetyltransferase -
LQ176_RS18620 (3793394) 3793394..3793864 + 471 WP_003021724.1 YlaC family protein -
LQ176_RS18625 (3793943) 3793943..3794083 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
LQ176_RS18630 (3794085) 3794085..3794345 - 261 WP_003021719.1 type B 50S ribosomal protein L31 -
LQ176_RS18635 (3794534) 3794534..3796087 + 1554 WP_044699371.1 EAL domain-containing protein -
LQ176_RS18640 (3796139) 3796139..3796492 - 354 WP_003831033.1 DUF1428 family protein -
LQ176_RS18645 (3796557) 3796557..3797186 - 630 WP_003835929.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T295781 WP_002892050.1 NZ_OW967263:3792201-3792419 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT295781 WP_003021733.1 NZ_OW967263:3791799-3792173 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References