Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 852731..853385 Replicon chromosome
Accession NZ_OW967263
Organism Citrobacter freundii isolate 22

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag LQ176_RS04155 Protein ID WP_003026936.1
Coordinates 852978..853385 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag LQ176_RS04150 Protein ID WP_003026938.1
Coordinates 852731..852997 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ176_RS04125 (847932) 847932..849365 - 1434 WP_044700805.1 6-phospho-beta-glucosidase BglA -
LQ176_RS04130 (849486) 849486..850214 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
LQ176_RS04135 (850267) 850267..850578 + 312 WP_044700802.1 N(4)-acetylcytidine aminohydrolase -
LQ176_RS04140 (850741) 850741..851400 + 660 WP_003838267.1 hemolysin III family protein -
LQ176_RS04145 (851494) 851494..852474 - 981 WP_003026944.1 tRNA-modifying protein YgfZ -
LQ176_RS04150 (852731) 852731..852997 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
LQ176_RS04155 (852978) 852978..853385 + 408 WP_003026936.1 protein YgfX Toxin
LQ176_RS04160 (853430) 853430..853951 - 522 WP_003026933.1 flavodoxin FldB -
LQ176_RS04165 (854065) 854065..854961 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
LQ176_RS04170 (854985) 854985..855698 + 714 WP_003026923.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ176_RS04175 (855704) 855704..857437 + 1734 WP_044700800.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T295776 WP_003026936.1 NZ_OW967263:852978-853385 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT295776 WP_003026938.1 NZ_OW967263:852731-852997 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References