295772

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4467..5160 Replicon plasmid P1
Accession NZ_OW967179
Organism Escherichia coli isolate 362

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag LQ124_RS23120 Protein ID WP_000182276.1
Coordinates 4804..5160 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag LQ124_RS23115 Protein ID WP_001172026.1
Coordinates 4467..4802 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ124_RS23090 (AI2821V1_4423) 1..1056 + 1056 WP_015060006.1 plasmid replication initiator RepA -
LQ124_RS23095 (AI2821V1_4424) 2013..3233 - 1221 WP_230133249.1 HD-GYP domain-containing protein -
LQ124_RS23100 (AI2821V1_4425) 3390..3770 - 381 WP_001054412.1 hypothetical protein -
LQ124_RS23105 (AI2821V1_4426) 3767..4093 - 327 WP_000091614.1 hypothetical protein -
LQ124_RS23110 (AI2821V1_4427) 4117..4452 - 336 WP_000741275.1 hypothetical protein -
LQ124_RS23115 (AI2821V1_4428) 4467..4802 - 336 WP_001172026.1 helix-turn-helix transcriptional regulator Antitoxin
LQ124_RS23120 (AI2821V1_4429) 4804..5160 - 357 WP_000182276.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ124_RS23125 (AI2821V1_4430) 5352..5954 + 603 WP_010465829.1 recombinase family protein -
LQ124_RS23130 (AI2821V1_4431) 5938..8967 + 3030 WP_032432545.1 Tn3 family transposase -
LQ124_RS23615 9438..9533 + 96 WP_004206884.1 DinQ-like type I toxin DqlB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaOXA-48 - 1..70748 70748


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12912.93 Da        Isoelectric Point: 8.9018

>T295772 WP_000182276.1 NZ_OW967179:c5160-4804 [Escherichia coli]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKELKGFGGAGVLKVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQEL

Download         Length: 357 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT295772 WP_001172026.1 NZ_OW967179:c4802-4467 [Escherichia coli]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References