Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4379326..4379823 Replicon chromosome
Accession NZ_OW967178
Organism Escherichia coli isolate 362

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag LQ124_RS20870 Protein ID WP_001173343.1
Coordinates 4379326..4379499 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag LQ124_RS20875 Protein ID WP_000398619.1
Coordinates 4379527..4379823 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ124_RS20860 (4375996) 4375996..4377453 + 1458 WP_000856827.1 dipeptide/tripeptide permease DtpC -
LQ124_RS20865 (4377690) 4377690..4379207 + 1518 WP_000003806.1 lysine--tRNA ligase -
LQ124_RS20870 (4379326) 4379326..4379499 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
LQ124_RS20875 (4379527) 4379527..4379823 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
LQ124_RS20880 (4380052) 4380052..4380324 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
LQ124_RS20885 (4380336) 4380336..4380566 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
LQ124_RS20890 (4380747) 4380747..4382378 + 1632 WP_001216477.1 sensor histidine kinase -
LQ124_RS20895 (4382375) 4382375..4383094 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T295770 WP_001173343.1 NZ_OW967178:c4379499-4379326 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT295770 WP_000398619.1 NZ_OW967178:c4379823-4379527 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References