Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4284231..4284826 Replicon chromosome
Accession NZ_OW967178
Organism Escherichia coli isolate 362

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag LQ124_RS20385 Protein ID WP_000239581.1
Coordinates 4284231..4284581 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag LQ124_RS20390 Protein ID WP_001223213.1
Coordinates 4284575..4284826 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ124_RS20365 (4279676) 4279676..4280698 - 1023 WP_001316039.1 ABC transporter permease -
LQ124_RS20370 (4280712) 4280712..4282214 - 1503 WP_230133213.1 sugar ABC transporter ATP-binding protein -
LQ124_RS20375 (4282347) 4282347..4283312 - 966 WP_001589575.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LQ124_RS20380 (4283622) 4283622..4284152 + 531 WP_000055075.1 inorganic diphosphatase -
LQ124_RS20385 (4284231) 4284231..4284581 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
LQ124_RS20390 (4284575) 4284575..4284826 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LQ124_RS20395 (4285038) 4285038..4285379 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
LQ124_RS20400 (4285382) 4285382..4289161 - 3780 WP_001589573.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T295769 WP_000239581.1 NZ_OW967178:c4284581-4284231 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT295769 WP_001223213.1 NZ_OW967178:c4284826-4284575 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References