Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4272750..4273272 Replicon chromosome
Accession NZ_OW967178
Organism Escherichia coli isolate 362

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag LQ124_RS20325 Protein ID WP_001105433.1
Coordinates 4272750..4273040 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag LQ124_RS20330 Protein ID WP_000212715.1
Coordinates 4273030..4273272 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ124_RS20305 (4267914) 4267914..4269569 + 1656 WP_001589577.1 alpha,alpha-phosphotrehalase -
LQ124_RS20310 (4269963) 4269963..4272101 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
LQ124_RS20315 (4272117) 4272117..4272296 - 180 WP_164477127.1 hypothetical protein -
LQ124_RS20320 (4272285) 4272285..4272749 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LQ124_RS20325 (4272750) 4272750..4273040 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ124_RS20330 (4273030) 4273030..4273272 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LQ124_RS20335 (4273464) 4273464..4273850 - 387 WP_001232246.1 cytochrome b562 -
LQ124_RS20340 (4274034) 4274034..4275386 - 1353 WP_001162173.1 metalloprotease PmbA -
LQ124_RS20345 (4275480) 4275480..4276031 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
LQ124_RS20350 (4276114) 4276114..4277487 - 1374 WP_001219792.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T295768 WP_001105433.1 NZ_OW967178:c4273040-4272750 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT295768 WP_000212715.1 NZ_OW967178:c4273272-4273030 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References