Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3581693..3582311 Replicon chromosome
Accession NZ_OW967178
Organism Escherichia coli isolate 362

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LQ124_RS17105 Protein ID WP_001291435.1
Coordinates 3582093..3582311 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LQ124_RS17100 Protein ID WP_000344800.1
Coordinates 3581693..3582067 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ124_RS17090 (3576782) 3576782..3577975 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ124_RS17095 (3577998) 3577998..3581147 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
LQ124_RS17100 (3581693) 3581693..3582067 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LQ124_RS17105 (3582093) 3582093..3582311 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LQ124_RS17110 (3582483) 3582483..3583034 + 552 WP_001589809.1 maltose O-acetyltransferase -
LQ124_RS17115 (3583151) 3583151..3583621 + 471 WP_000136192.1 YlaC family protein -
LQ124_RS17120 (3583785) 3583785..3585335 + 1551 WP_001389864.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LQ124_RS17125 (3585377) 3585377..3585730 - 354 WP_000878140.1 DUF1428 domain-containing protein -
LQ124_RS17135 (3586109) 3586109..3586420 + 312 WP_000409911.1 MGMT family protein -
LQ124_RS17140 (3586451) 3586451..3587023 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T295766 WP_001291435.1 NZ_OW967178:3582093-3582311 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT295766 WP_000344800.1 NZ_OW967178:3581693-3582067 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References