Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3180739..3181444 Replicon chromosome
Accession NZ_OW967178
Organism Escherichia coli isolate 362

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag LQ124_RS15305 Protein ID WP_000539521.1
Coordinates 3180739..3181125 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LQ124_RS15310 Protein ID WP_001280945.1
Coordinates 3181115..3181444 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ124_RS15285 (3176743) 3176743..3177369 + 627 WP_001328219.1 glutathione S-transferase GstB -
LQ124_RS15290 (3177366) 3177366..3178481 - 1116 WP_000555049.1 aldose sugar dehydrogenase YliI -
LQ124_RS15295 (3178592) 3178592..3178975 - 384 WP_000497137.1 biofilm formation regulator BssR -
LQ124_RS15300 (3179188) 3179188..3180513 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
LQ124_RS15305 (3180739) 3180739..3181125 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ124_RS15310 (3181115) 3181115..3181444 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
LQ124_RS15315 (3181514) 3181514..3182842 - 1329 WP_000086868.1 GGDEF domain-containing protein -
LQ124_RS15320 (3182850) 3182850..3185198 - 2349 WP_001328220.1 EAL domain-containing protein -
LQ124_RS15325 (3185376) 3185376..3186287 - 912 WP_001236018.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T295765 WP_000539521.1 NZ_OW967178:3180739-3181125 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT295765 WP_001280945.1 NZ_OW967178:3181115-3181444 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References