Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2576163..2577751 Replicon chromosome
Accession NZ_OW967178
Organism Escherichia coli isolate 362

Toxin (Protein)


Gene name hipA Uniprot ID V0Z3Q2
Locus tag LQ124_RS12320 Protein ID WP_001125418.1
Coordinates 2576163..2577485 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LQ124_RS12325 Protein ID WP_230133166.1
Coordinates 2577485..2577751 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ124_RS12290 (2571286) 2571286..2571858 - 573 WP_000789794.1 NAD(P)H-dependent oxidoreductase -
LQ124_RS12295 (2572009) 2572009..2572596 - 588 WP_024190054.1 amidohydrolase family protein -
LQ124_RS12300 (2572699) 2572699..2573646 - 948 WP_230133165.1 aldo/keto reductase -
LQ124_RS12305 (2573720) 2573720..2574409 - 690 WP_000801313.1 type 1 glutamine amidotransferase domain-containing protein -
LQ124_RS12310 (2574418) 2574418..2574726 - 309 WP_001221046.1 hypothetical protein -
LQ124_RS12315 (2574865) 2574865..2575764 + 900 WP_001551125.1 LysR family transcriptional regulator -
LQ124_RS12320 (2576163) 2576163..2577485 - 1323 WP_001125418.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
LQ124_RS12325 (2577485) 2577485..2577751 - 267 WP_230133166.1 type II toxin-antitoxin system antitoxin HipB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49316.95 Da        Isoelectric Point: 8.5823

>T295764 WP_001125418.1 NZ_OW967178:c2577485-2576163 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9975.37 Da        Isoelectric Point: 7.9779

>AT295764 WP_230133166.1 NZ_OW967178:c2577751-2577485 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSGLAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEKQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0Z3Q2

Antitoxin

Source ID Structure

References