Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2473797..2474435 Replicon chromosome
Accession NZ_OW967178
Organism Escherichia coli isolate 362

Toxin (Protein)


Gene name hicA Uniprot ID B7N4J4
Locus tag LQ124_RS11885 Protein ID WP_000813797.1
Coordinates 2473797..2473973 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LQ124_RS11890 Protein ID WP_001270286.1
Coordinates 2474019..2474435 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ124_RS11865 (2469419) 2469419..2470591 - 1173 WP_001236217.1 BenE family transporter YdcO -
LQ124_RS11870 (2470683) 2470683..2471219 + 537 WP_000429505.1 DNA-binding transcriptional regulator SutR -
LQ124_RS11875 (2471292) 2471292..2473253 + 1962 WP_001445698.1 23S rRNA 5-hydroxycytidine C2501 synthase -
LQ124_RS11880 (2473345) 2473345..2473575 - 231 WP_000491976.1 YncJ family protein -
LQ124_RS11885 (2473797) 2473797..2473973 + 177 WP_000813797.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LQ124_RS11890 (2474019) 2474019..2474435 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LQ124_RS11895 (2474514) 2474514..2475920 + 1407 WP_000760596.1 PLP-dependent aminotransferase family protein -
LQ124_RS11900 (2476165) 2476165..2477310 + 1146 WP_000047452.1 ABC transporter substrate-binding protein -
LQ124_RS11905 (2477328) 2477328..2478341 + 1014 WP_000220411.1 ABC transporter ATP-binding protein -
LQ124_RS11910 (2478342) 2478342..2479283 + 942 WP_001578312.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6724.76 Da        Isoelectric Point: 11.5666

>T295763 WP_000813797.1 NZ_OW967178:2473797-2473973 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPSDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT295763 WP_001270286.1 NZ_OW967178:2474019-2474435 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829J715

Antitoxin

Source ID Structure

References