Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2200352..2200866 Replicon chromosome
Accession NC_021554
Organism Staphylococcus aureus CA-347

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag CA347_RS11185 Protein ID WP_000581795.1
Coordinates 2200352..2200561 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag CA347_RS11190 Protein ID WP_000138930.1
Coordinates 2200573..2200866 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA347_RS11165 2195860..2197218 - 1359 WP_000611479.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
CA347_RS11170 2197233..2198303 - 1071 WP_000159637.1 D-alanine--D-alanine ligase -
CA347_RS11175 2198621..2199823 + 1203 WP_001109939.1 rod shape-determining protein RodA -
CA347_RS11180 2200087..2200224 - 138 WP_000828354.1 hypothetical protein -
CA347_RS11185 2200352..2200561 - 210 WP_000581795.1 heavy-metal-associated domain-containing protein Toxin
CA347_RS11190 2200573..2200866 - 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
CA347_RS11195 2201032..2202516 + 1485 WP_000571562.1 cardiolipin synthase -
CA347_RS11200 2202544..2203191 + 648 WP_001187625.1 HD domain-containing protein -
CA347_RS11205 2203741..2204613 - 873 WP_000725802.1 membrane protein insertase YidC -
CA347_RS11210 2204699..2205340 - 642 WP_000483162.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T29576 WP_000581795.1 NC_021554:c2200561-2200352 [Staphylococcus aureus CA-347]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T29576 NC_021554:c2200561-2200352 [Staphylococcus aureus CA-347]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAAAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT29576 WP_000138930.1 NC_021554:c2200866-2200573 [Staphylococcus aureus CA-347]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT29576 NC_021554:c2200866-2200573 [Staphylococcus aureus CA-347]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAAAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CATTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References