Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 905251..905905 Replicon chromosome
Accession NZ_OW967178
Organism Escherichia coli isolate 362

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag LQ124_RS04300 Protein ID WP_000244781.1
Coordinates 905498..905905 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag LQ124_RS04295 Protein ID WP_000354046.1
Coordinates 905251..905517 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ124_RS04275 (901339) 901339..902772 - 1434 WP_001389468.1 6-phospho-beta-glucosidase BglA -
LQ124_RS04280 (902817) 902817..903128 + 312 WP_001182952.1 N(4)-acetylcytidine aminohydrolase -
LQ124_RS04285 (903292) 903292..903951 + 660 WP_000250269.1 hemolysin III family protein -
LQ124_RS04290 (904028) 904028..905008 - 981 WP_001578935.1 tRNA-modifying protein YgfZ -
LQ124_RS04295 (905251) 905251..905517 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
LQ124_RS04300 (905498) 905498..905905 + 408 WP_000244781.1 protein YgfX Toxin
LQ124_RS04305 (905945) 905945..906466 - 522 WP_001055874.1 flavodoxin FldB -
LQ124_RS04310 (906578) 906578..907474 + 897 WP_000806652.1 site-specific tyrosine recombinase XerD -
LQ124_RS04315 (907499) 907499..908209 + 711 WP_000715221.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ124_RS04320 (908215) 908215..909948 + 1734 WP_001590643.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T295756 WP_000244781.1 NZ_OW967178:905498-905905 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT295756 WP_000354046.1 NZ_OW967178:905251-905517 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References