Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 152559..153171 Replicon chromosome
Accession NZ_OW967178
Organism Escherichia coli isolate 362

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag LQ124_RS00665 Protein ID WP_000833473.1
Coordinates 152559..152744 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1V3VHB3
Locus tag LQ124_RS00670 Protein ID WP_000499746.1
Coordinates 152761..153171 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ124_RS00655 (149390) 149390..150541 + 1152 WP_000741502.1 L-threonine dehydrogenase -
LQ124_RS00660 (150743) 150743..152281 + 1539 WP_000183978.1 aldehyde dehydrogenase AldB -
LQ124_RS00665 (152559) 152559..152744 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
LQ124_RS00670 (152761) 152761..153171 + 411 WP_000499746.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LQ124_RS00675 (153243) 153243..155207 - 1965 WP_001579218.1 glycoside hydrolase family 127 protein -
LQ124_RS00680 (155218) 155218..156618 - 1401 WP_000204809.1 MFS transporter -
LQ124_RS00685 (156844) 156844..157659 + 816 WP_001590865.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T295754 WP_000833473.1 NZ_OW967178:152559-152744 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15290.22 Da        Isoelectric Point: 4.5486

>AT295754 WP_000499746.1 NZ_OW967178:152761-153171 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDYAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A1V3VHB3

References