Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4283126..4283780 Replicon chromosome
Accession NZ_OW967003
Organism Escherichia coli isolate 624

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag LQ179_RS20610 Protein ID WP_000244781.1
Coordinates 4283373..4283780 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag LQ179_RS20605 Protein ID WP_000354046.1
Coordinates 4283126..4283392 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ179_RS20585 (4279214) 4279214..4280647 - 1434 WP_001394742.1 6-phospho-beta-glucosidase BglA -
LQ179_RS20590 (4280692) 4280692..4281003 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
LQ179_RS20595 (4281167) 4281167..4281826 + 660 WP_000250274.1 hemolysin III family protein -
LQ179_RS20600 (4281903) 4281903..4282883 - 981 WP_000886087.1 tRNA-modifying protein YgfZ -
LQ179_RS20605 (4283126) 4283126..4283392 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
LQ179_RS20610 (4283373) 4283373..4283780 + 408 WP_000244781.1 protein YgfX Toxin
LQ179_RS20615 (4283820) 4283820..4284341 - 522 WP_001055874.1 flavodoxin FldB -
LQ179_RS20620 (4284453) 4284453..4285349 + 897 WP_000806650.1 site-specific tyrosine recombinase XerD -
LQ179_RS20625 (4285374) 4285374..4286084 + 711 WP_000715222.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ179_RS20630 (4286090) 4286090..4287823 + 1734 WP_000813233.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T295749 WP_000244781.1 NZ_OW967003:4283373-4283780 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT295749 WP_000354046.1 NZ_OW967003:4283126-4283392 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References