Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4172213..4173032 Replicon chromosome
Accession NZ_OW967003
Organism Escherichia coli isolate 624

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag LQ179_RS20040 Protein ID WP_230138841.1
Coordinates 4172213..4172590 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag LQ179_RS20045 Protein ID WP_230138842.1
Coordinates 4172679..4173032 (-) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ179_RS20020 (4170011) 4170011..4171231 + 1221 WP_000794251.1 capsular biosynthesis protein -
LQ179_RS20025 (4171257) 4171257..4171487 - 231 Protein_3920 hypothetical protein -
LQ179_RS20030 (4171593) 4171593..4171769 - 177 WP_000839288.1 DUF957 domain-containing protein -
LQ179_RS20035 (4171786) 4171786..4172216 - 431 Protein_3922 DUF5983 family protein -
LQ179_RS20040 (4172213) 4172213..4172590 - 378 WP_230138841.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
LQ179_RS20045 (4172679) 4172679..4173032 - 354 WP_230138842.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
LQ179_RS20050 (4173106) 4173106..4173327 - 222 WP_000692323.1 DUF987 domain-containing protein -
LQ179_RS20055 (4173390) 4173390..4173866 - 477 WP_001186773.1 RadC family protein -
LQ179_RS20060 (4173882) 4173882..4174367 - 486 WP_230138843.1 antirestriction protein -
LQ179_RS20065 (4174459) 4174459..4175280 - 822 WP_230138844.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - ugd / kpsS 4148235..4193676 45441


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14101.15 Da        Isoelectric Point: 7.2436

>T295748 WP_230138841.1 NZ_OW967003:c4172590-4172213 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNIILGKHPEVKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13084.91 Da        Isoelectric Point: 6.0567

>AT295748 WP_230138842.1 NZ_OW967003:c4173032-4172679 [Escherichia coli]
VSDTLPDDNQDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPR
HQHTVTLYAKGLTCKADTLGSCGYVYLAVYPTPEMKN

Download         Length: 354 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References