Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2571019..2571614 Replicon chromosome
Accession NZ_OW967003
Organism Escherichia coli isolate 624

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag LQ179_RS12315 Protein ID WP_000239581.1
Coordinates 2571019..2571369 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag LQ179_RS12320 Protein ID WP_001223213.1
Coordinates 2571363..2571614 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ179_RS12295 (2566473) 2566473..2567495 - 1023 WP_001298067.1 ABC transporter permease -
LQ179_RS12300 (2567509) 2567509..2569011 - 1503 WP_022646474.1 sugar ABC transporter ATP-binding protein -
LQ179_RS12305 (2569144) 2569144..2570100 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LQ179_RS12310 (2570410) 2570410..2570940 + 531 WP_000055075.1 inorganic diphosphatase -
LQ179_RS12315 (2571019) 2571019..2571369 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
LQ179_RS12320 (2571363) 2571363..2571614 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LQ179_RS12325 (2571826) 2571826..2572167 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
LQ179_RS12330 (2572170) 2572170..2575949 - 3780 WP_022646473.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T295743 WP_000239581.1 NZ_OW967003:c2571369-2571019 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT295743 WP_001223213.1 NZ_OW967003:c2571614-2571363 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References