Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1873634..1874252 Replicon chromosome
Accession NZ_OW967003
Organism Escherichia coli isolate 624

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LQ179_RS09115 Protein ID WP_001291435.1
Coordinates 1874034..1874252 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LQ179_RS09110 Protein ID WP_000344800.1
Coordinates 1873634..1874008 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ179_RS09100 (1868723) 1868723..1869916 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ179_RS09105 (1869939) 1869939..1873088 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
LQ179_RS09110 (1873634) 1873634..1874008 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LQ179_RS09115 (1874034) 1874034..1874252 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LQ179_RS09120 (1874424) 1874424..1874975 + 552 WP_000102574.1 maltose O-acetyltransferase -
LQ179_RS09125 (1875091) 1875091..1875561 + 471 WP_022645280.1 YlaC family protein -
LQ179_RS09130 (1875725) 1875725..1877275 + 1551 WP_022645279.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LQ179_RS09135 (1877317) 1877317..1877670 - 354 WP_000878140.1 DUF1428 domain-containing protein -
LQ179_RS09145 (1878049) 1878049..1878360 + 312 WP_000409911.1 MGMT family protein -
LQ179_RS09150 (1878391) 1878391..1878963 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T295739 WP_001291435.1 NZ_OW967003:1874034-1874252 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT295739 WP_000344800.1 NZ_OW967003:1873634-1874008 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References