Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1457960..1458665 Replicon chromosome
Accession NZ_OW967003
Organism Escherichia coli isolate 624

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag LQ179_RS07250 Protein ID WP_000539521.1
Coordinates 1457960..1458346 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LQ179_RS07255 Protein ID WP_001280945.1
Coordinates 1458336..1458665 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ179_RS07230 (1453964) 1453964..1454590 + 627 WP_001295292.1 glutathione S-transferase GstB -
LQ179_RS07235 (1454587) 1454587..1455702 - 1116 WP_000554964.1 aldose sugar dehydrogenase YliI -
LQ179_RS07240 (1455813) 1455813..1456196 - 384 WP_000497137.1 biofilm formation regulator BssR -
LQ179_RS07245 (1456409) 1456409..1457734 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
LQ179_RS07250 (1457960) 1457960..1458346 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ179_RS07255 (1458336) 1458336..1458665 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
LQ179_RS07260 (1458735) 1458735..1460012 - 1278 WP_230138809.1 GGDEF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T295737 WP_000539521.1 NZ_OW967003:1457960-1458346 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT295737 WP_001280945.1 NZ_OW967003:1458336-1458665 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References