Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1201964..1202748 Replicon chromosome
Accession NZ_OW967003
Organism Escherichia coli isolate 624

Toxin (Protein)


Gene name TacT2 Uniprot ID V0T0H9
Locus tag LQ179_RS06045 Protein ID WP_000613626.1
Coordinates 1202254..1202748 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A0A1AEM7
Locus tag LQ179_RS06040 Protein ID WP_024946541.1
Coordinates 1201964..1202257 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ179_RS06030 (1197125) 1197125..1198084 - 960 WP_022645527.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -
LQ179_RS06035 (1198657) 1198657..1201830 + 3174 WP_063814920.1 ribonuclease E -
LQ179_RS06040 (1201964) 1201964..1202257 + 294 WP_024946541.1 DUF1778 domain-containing protein Antitoxin
LQ179_RS06045 (1202254) 1202254..1202748 + 495 WP_000613626.1 GNAT family N-acetyltransferase Toxin
LQ179_RS06050 (1202843) 1202843..1203796 - 954 WP_022645524.1 flagellar hook-associated protein FlgL -
LQ179_RS06055 (1203808) 1203808..1205451 - 1644 WP_022645523.1 flagellar hook-associated protein FlgK -
LQ179_RS06060 (1205517) 1205517..1206458 - 942 WP_001317765.1 flagellar assembly peptidoglycan hydrolase FlgJ -
LQ179_RS06065 (1206458) 1206458..1207555 - 1098 WP_021580666.1 flagellar basal body P-ring protein FlgI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18084.00 Da        Isoelectric Point: 8.2617

>T295736 WP_000613626.1 NZ_OW967003:1202254-1202748 [Escherichia coli]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIGRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11039.60 Da        Isoelectric Point: 10.5423

>AT295736 WP_024946541.1 NZ_OW967003:1201964-1202257 [Escherichia coli]
MAAANNIPARRESLNLRIKPAERDLIDRAAKARGKNRSEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0T0H9

Antitoxin

Source ID Structure
AlphaFold DB A0A0A1AEM7

References