Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 715323..715961 Replicon chromosome
Accession NZ_OW967003
Organism Escherichia coli isolate 624

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag LQ179_RS03670 Protein ID WP_000813794.1
Coordinates 715323..715499 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LQ179_RS03675 Protein ID WP_001270286.1
Coordinates 715545..715961 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ179_RS03650 (710945) 710945..712117 - 1173 WP_230138799.1 BenE family transporter YdcO -
LQ179_RS03655 (712209) 712209..712745 + 537 WP_000429148.1 DNA-binding transcriptional regulator SutR -
LQ179_RS03660 (712818) 712818..714779 + 1962 WP_077737811.1 23S rRNA 5-hydroxycytidine C2501 synthase -
LQ179_RS03665 (714871) 714871..715101 - 231 WP_000491567.1 DUF2554 family protein -
LQ179_RS03670 (715323) 715323..715499 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LQ179_RS03675 (715545) 715545..715961 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LQ179_RS03680 (716040) 716040..717446 + 1407 WP_022645665.1 PLP-dependent aminotransferase family protein -
LQ179_RS03685 (717691) 717691..718836 + 1146 WP_000047466.1 ABC transporter substrate-binding protein -
LQ179_RS03690 (718854) 718854..719867 + 1014 WP_022645666.1 ABC transporter ATP-binding protein -
LQ179_RS03695 (719868) 719868..720809 + 942 WP_022645667.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T295735 WP_000813794.1 NZ_OW967003:715323-715499 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT295735 WP_001270286.1 NZ_OW967003:715545-715961 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References