Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4934899..4935515 Replicon chromosome
Accession NZ_OW849527
Organism Citrobacter freundii isolate 22

Toxin (Protein)


Gene name vapC Uniprot ID A0A0J1MQ96
Locus tag LQ181_RS24085 Protein ID WP_003028682.1
Coordinates 4934899..4935273 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6B5NTK4
Locus tag LQ181_RS24090 Protein ID WP_043018956.1
Coordinates 4935273..4935515 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ181_RS24070 (4932402) 4932402..4933304 + 903 WP_003028691.1 formate dehydrogenase O subunit beta -
LQ181_RS24075 (4933301) 4933301..4933936 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
LQ181_RS24080 (4933933) 4933933..4934862 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
LQ181_RS24085 (4934899) 4934899..4935273 - 375 WP_003028682.1 type II toxin-antitoxin system VapC family toxin Toxin
LQ181_RS24090 (4935273) 4935273..4935515 - 243 WP_043018956.1 CopG family transcriptional regulator Antitoxin
LQ181_RS24095 (4935721) 4935721..4936629 + 909 WP_044701816.1 alpha/beta hydrolase -
LQ181_RS24100 (4936780) 4936780..4937721 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
LQ181_RS24105 (4937766) 4937766..4938203 - 438 WP_003028671.1 D-aminoacyl-tRNA deacylase -
LQ181_RS24110 (4938200) 4938200..4939072 - 873 WP_003028669.1 virulence factor BrkB family protein -
LQ181_RS24115 (4939066) 4939066..4939665 - 600 WP_016151258.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13674.89 Da        Isoelectric Point: 9.5622

>T295726 WP_003028682.1 NZ_OW849527:c4935273-4934899 [Citrobacter freundii]
MVKGSALFDTNILIDLFSGRNEAKLAIETWPPQNAISLITWMEVMVGAKKYHQEARTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTKDFAGLSGVVTPYTL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9451.75 Da        Isoelectric Point: 4.3437

>AT295726 WP_043018956.1 NZ_OW849527:c4935515-4935273 [Citrobacter freundii]
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MQ96

Antitoxin

Source ID Structure
AlphaFold DB A0A6B5NTK4

References