Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4526834..4527350 Replicon chromosome
Accession NZ_OW849527
Organism Citrobacter freundii isolate 22

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LQ181_RS22185 Protein ID WP_044699148.1
Coordinates 4526834..4527118 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag LQ181_RS22190 Protein ID WP_003839576.1
Coordinates 4527108..4527350 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ181_RS22170 (4523159) 4523159..4523743 + 585 WP_003839584.1 fructose PTS transporter subunit IIA -
LQ181_RS22175 (4524121) 4524121..4526259 + 2139 WP_003025782.1 anaerobic ribonucleoside-triphosphate reductase -
LQ181_RS22180 (4526366) 4526366..4526830 + 465 WP_032937736.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LQ181_RS22185 (4526834) 4526834..4527118 - 285 WP_044699148.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ181_RS22190 (4527108) 4527108..4527350 - 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LQ181_RS22195 (4527428) 4527428..4529341 - 1914 WP_003839574.1 BglG family transcription antiterminator -
LQ181_RS22200 (4529363) 4529363..4530103 - 741 WP_044699149.1 KDGP aldolase family protein -
LQ181_RS22205 (4530100) 4530100..4531218 - 1119 WP_044699152.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LQ181_RS22210 (4531202) 4531202..4532335 - 1134 WP_016149471.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10865.69 Da        Isoelectric Point: 10.1988

>T295724 WP_044699148.1 NZ_OW849527:c4527118-4526834 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVTVFVVAVGK
RQHSAVYLDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT295724 WP_003839576.1 NZ_OW849527:c4527350-4527108 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References