Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 4045600..4046279 Replicon chromosome
Accession NZ_OW849527
Organism Citrobacter freundii isolate 22

Toxin (Protein)


Gene name ykfI Uniprot ID A0A1B7JLK7
Locus tag LQ181_RS19860 Protein ID WP_003031349.1
Coordinates 4045938..4046279 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID A0A1B7JLJ2
Locus tag LQ181_RS19855 Protein ID WP_003031347.1
Coordinates 4045600..4045917 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ181_RS19830 (4041693) 4041693..4043690 - 1998 WP_016245729.1 choline BCCT transporter BetT -
LQ181_RS19835 (4044238) 4044238..4044385 + 148 Protein_3890 hypothetical protein -
LQ181_RS19840 (4044399) 4044399..4044860 + 462 WP_003031344.1 antirestriction protein -
LQ181_RS19845 (4044876) 4044876..4045352 + 477 WP_003031345.1 RadC family protein -
LQ181_RS19850 (4045361) 4045361..4045582 + 222 WP_003031346.1 DUF987 domain-containing protein -
LQ181_RS19855 (4045600) 4045600..4045917 + 318 WP_003031347.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LQ181_RS19860 (4045938) 4045938..4046279 + 342 WP_003031349.1 type IV toxin-antitoxin system toxin YkfI Toxin
LQ181_RS19865 (4046869) 4046869..4047471 - 603 WP_224770543.1 tail fiber assembly protein -
LQ181_RS19870 (4047473) 4047473..4048924 - 1452 WP_224770544.1 hypothetical protein -
LQ181_RS19875 (4048924) 4048924..4049604 - 681 WP_121927014.1 DUF2612 domain-containing protein -
LQ181_RS19880 (4049601) 4049601..4050800 - 1200 WP_121927013.1 baseplate J/gp47 family protein -
LQ181_RS19885 (4050801) 4050801..4051154 - 354 WP_016239889.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12921.01 Da        Isoelectric Point: 9.6543

>T295723 WP_003031349.1 NZ_OW849527:4045938-4046279 [Citrobacter freundii]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRQSRNNVVR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12094.74 Da        Isoelectric Point: 7.0370

>AT295723 WP_003031347.1 NZ_OW849527:4045600-4045917 [Citrobacter freundii]
MSKITWGLQRDITPRLGARLVQEGNRLHYLADRASMTGKFSDIEYRKLDETFPHFIRQMESMLTTGELSTHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B7JLK7

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7JLJ2

References