Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3809946..3810566 Replicon chromosome
Accession NZ_OW849527
Organism Citrobacter freundii isolate 22

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LQ181_RS18760 Protein ID WP_002892050.1
Coordinates 3810348..3810566 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag LQ181_RS18755 Protein ID WP_003021733.1
Coordinates 3809946..3810320 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ181_RS18745 (3805093) 3805093..3806286 + 1194 WP_003835922.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ181_RS18750 (3806309) 3806309..3809458 + 3150 WP_003021736.1 efflux RND transporter permease AcrB -
LQ181_RS18755 (3809946) 3809946..3810320 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
LQ181_RS18760 (3810348) 3810348..3810566 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LQ181_RS18765 (3810873) 3810873..3811424 + 552 WP_044699372.1 maltose O-acetyltransferase -
LQ181_RS18770 (3811541) 3811541..3812011 + 471 WP_003021724.1 YlaC family protein -
LQ181_RS18775 (3812090) 3812090..3812230 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
LQ181_RS18780 (3812232) 3812232..3812492 - 261 WP_003021719.1 type B 50S ribosomal protein L31 -
LQ181_RS18785 (3812681) 3812681..3814234 + 1554 WP_044699371.1 EAL domain-containing protein -
LQ181_RS18790 (3814286) 3814286..3814639 - 354 WP_003831033.1 DUF1428 family protein -
LQ181_RS18795 (3814704) 3814704..3815333 - 630 WP_003835929.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T295722 WP_002892050.1 NZ_OW849527:3810348-3810566 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT295722 WP_003021733.1 NZ_OW849527:3809946-3810320 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References