Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 2014713..2015510 Replicon chromosome
Accession NC_021554
Organism Staphylococcus aureus CA-347

Toxin (Protein)


Gene name - Uniprot ID A0A6B0AWK0
Locus tag CA347_RS10120 Protein ID WP_000525016.1
Coordinates 2015049..2015510 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag CA347_RS10115 Protein ID WP_001260487.1
Coordinates 2014713..2015036 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA347_RS15085 2010314..2010577 - 264 WP_001205732.1 hypothetical protein -
CA347_RS10070 2010586..2010846 - 261 WP_000291089.1 DUF1108 family protein -
CA347_RS10075 2010940..2011101 - 162 WP_000066011.1 DUF1270 domain-containing protein -
CA347_RS10080 2011094..2011315 - 222 WP_000594789.1 hypothetical protein -
CA347_RS10085 2011386..2011616 + 231 WP_000395455.1 hypothetical protein -
CA347_RS10090 2011954..2012157 - 204 WP_016528750.1 hypothetical protein -
CA347_RS10095 2012173..2012961 - 789 WP_001148568.1 phage antirepressor KilAC domain-containing protein -
CA347_RS10100 2012990..2013766 - 777 WP_016528751.1 Rha family transcriptional regulator -
CA347_RS10105 2013823..2014152 + 330 WP_000514498.1 hypothetical protein -
CA347_RS15590 2014127..2014285 - 159 WP_000398750.1 hypothetical protein -
CA347_RS10110 2014301..2014549 - 249 WP_000272858.1 helix-turn-helix domain-containing protein -
CA347_RS10115 2014713..2015036 + 324 WP_001260487.1 helix-turn-helix domain-containing protein Antitoxin
CA347_RS10120 2015049..2015510 + 462 WP_000525016.1 hypothetical protein Toxin
CA347_RS10125 2015864..2016910 + 1047 WP_016528752.1 site-specific integrase -
CA347_RS10130 2016955..2018100 + 1146 WP_001622132.1 radical SAM/CxCxxxxC motif protein YfkAB -
CA347_RS10135 2018363..2018893 - 531 WP_000184383.1 acyl-CoA thioesterase -
CA347_RS10140 2018983..2020230 - 1248 WP_001622131.1 aminopeptidase -
CA347_RS10145 2020242..2020442 - 201 WP_000180459.1 DUF1128 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1972697..2016910 44213


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 17993.29 Da        Isoelectric Point: 4.5941

>T29572 WP_000525016.1 NC_021554:2015049-2015510 [Staphylococcus aureus CA-347]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDTEKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFTSAVPIREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T29572 NC_021554:2015049-2015510 [Staphylococcus aureus CA-347]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATCTAATTTTAATAAAGCGTGGTTTATCAGATACAGAAAAGGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCTGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTATGCACGT
AGACATGGTTTTACTTCAGCTGTACCGATACGTGAAATTGTAGAAGCTTACAATTATGGCGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTGGAGGCAATAGAACAATATAAGAAGATATACGGTATTGGAACTC
ACTATGGCGAGTATTCGATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAAGAAATATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT29572 WP_001260487.1 NC_021554:2014713-2015036 [Staphylococcus aureus CA-347]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT29572 NC_021554:2014713-2015036 [Staphylococcus aureus CA-347]
ATGAGAACTTCAGCAGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGAGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B0AWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References