Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 882686..883340 Replicon chromosome
Accession NZ_OW849527
Organism Citrobacter freundii isolate 22

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag LQ181_RS04370 Protein ID WP_003026936.1
Coordinates 882933..883340 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag LQ181_RS04365 Protein ID WP_003026938.1
Coordinates 882686..882952 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ181_RS04340 (877887) 877887..879320 - 1434 WP_044700805.1 6-phospho-beta-glucosidase BglA -
LQ181_RS04345 (879441) 879441..880169 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
LQ181_RS04350 (880222) 880222..880533 + 312 WP_044700802.1 N(4)-acetylcytidine aminohydrolase -
LQ181_RS04355 (880696) 880696..881355 + 660 WP_003838267.1 hemolysin III family protein -
LQ181_RS04360 (881449) 881449..882429 - 981 WP_003026944.1 tRNA-modifying protein YgfZ -
LQ181_RS04365 (882686) 882686..882952 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
LQ181_RS04370 (882933) 882933..883340 + 408 WP_003026936.1 protein YgfX Toxin
LQ181_RS04375 (883385) 883385..883906 - 522 WP_003026933.1 flavodoxin FldB -
LQ181_RS04380 (884020) 884020..884916 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
LQ181_RS04385 (884940) 884940..885653 + 714 WP_003026923.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ181_RS04390 (885659) 885659..887392 + 1734 WP_044700800.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T295717 WP_003026936.1 NZ_OW849527:882933-883340 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT295717 WP_003026938.1 NZ_OW849527:882686-882952 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References