Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 284447..285078 Replicon chromosome
Accession NZ_OW849527
Organism Citrobacter freundii isolate 22

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag LQ181_RS01325 Protein ID WP_003837806.1
Coordinates 284447..284722 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag LQ181_RS01330 Protein ID WP_003837808.1
Coordinates 284719..285078 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ181_RS01315 (280498) 280498..283245 + 2748 WP_044701369.1 ribosome-associated ATPase/putative transporter RbbA -
LQ181_RS01320 (283245) 283245..284369 + 1125 WP_003837801.1 ABC transporter permease -
LQ181_RS01325 (284447) 284447..284722 + 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
LQ181_RS01330 (284719) 284719..285078 + 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LQ181_RS01335 (285189) 285189..285590 - 402 WP_003023387.1 nickel-responsive transcriptional regulator NikR -
LQ181_RS01340 (285640) 285640..286218 - 579 WP_003837810.1 4'-phosphopantetheinyl transferase AcpT -
LQ181_RS01345 (286281) 286281..287330 - 1050 WP_003023393.1 AI-2E family transporter -
LQ181_RS01350 (287464) 287464..288681 + 1218 WP_003846164.1 MFS transporter -
LQ181_RS01355 (288685) 288685..289242 - 558 WP_003837816.1 DcrB family lipoprotein -
LQ181_RS01360 (289315) 289315..289980 - 666 WP_044701371.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T295715 WP_003837806.1 NZ_OW849527:284447-284722 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT295715 WP_003837808.1 NZ_OW849527:284719-285078 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References